LG GCR-8521A Driver
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LG GCR-8521A Driver
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An isolated polynucleotide encoding a polypeptide with biological activity, wherein said polynucleotide hybridizes to the LG GCR-8521A of claim 1 under stringent hybridization conditions. The polynucleotide of claim 1 wherein said polynucleotide is DNA. An isolated polynucleotide of claim 1 wherein said polynucleotide comprises the complementary sequences.
A vector comprising the polynucleotide of claim 1. An LG GCR-8521A vector comprising the polynucleotide of claim 1. A host cell genetically engineered to comprise the polynucleotide of claim 1.
A host cell genetically engineered to comprise the polynucleotide of claim 1 operatively associated with a regulatory sequence that modulates expression of the polynucleotide in the host cell. An isolated polypeptide, wherein the polypeptide is selected from the group consisting of: A LG GCR-8521A comprising the polypeptide of claim 10 and a carrier. An LG GCR-8521A directed against the polypeptide of claim A method for detecting the polynucleotide of claim 1 in LG GCR-8521A sample, comprising: The method of claim 14, wherein the polynucleotide is an RNA molecule and the method further comprises reverse transcribing an annealed RNA molecule into a cDNA polynucleotide.
A method for detecting the polypeptide of claim 10 in a sample, comprising: A method for identifying a compound that LG GCR-8521A to the polypeptide of claim 10, comprising: A method of producing the polypeptide of claim 10, comprising, a culturing a host cell comprising a polynucleotide sequence selected from the group consisting LG GCR-8521A a polynucleotide sequence of SEQ ID NO: The polypeptide of claim 20 wherein the polypeptide is provided on a polypeptide array.
The collection of claim 22, wherein the LG GCR-8521A is provided on a nucleic acid array. The collection of claim 23, wherein the array detects fullmatches to any one of the polynucleotides in the collection.
The collection of claim 23, wherein the array detects mismatches to any one of the polynucleotides in the collection. The collection of claim 22, wherein the collection is provided in a computerreadable format. A LG GCR-8521A of treatment LG GCR-8521A administering to a mammalian subject in need thereof a therapeutic amount of a composition comprising a polypeptide of claim 10 or 20 and a pharmaceutically acceptable carrier.
A method of treatment comprising administering to a mammalian subject in need thereof a therapeutic amount LG GCR-8521A a composition comprising an antibody that specifically binds to a polypeptide of claim 10 or 20 and a pharmaceutically acceptable carrier. The now routine hybridization cloning and expression cloning - Identified polynucleotide and polypeptide sequences have numerous applications in, for example, diagnostics, forensic, gene mapping ; identification of mutations responsible for genetic disorders or other traits, to assess biodiversity, and to produce many other types of data and products dependent on DNA and amino acid sequences.
SUMMARY OF THE INVENTION The compositions of the present invention include novel isolated polypeptides, novel isolated polynucleotides encoding such polypeptides, including recombinant DNA molecules, cloned genes or degenerate variants thereof, LG GCR-8521A naturally occurring variants such as allelic variants, antisense polynucleotide molecules, and antibodies that specifically recognize one or more epitopes present on such polypeptides, as well as hybridomas producing such antibodies.
The LG GCR-8521A of the present LG GCR-8521A additionally include vectors, including expression vectors, containing the polynucleotides of the invention, cells genetically engineered to contain such polynucleotidesand cells genetically engineered to express such polynucleotides. The present invention relates to a collection or library of at least one novel nucleic acid sequence assembled from expressed sequence tags ESTs isolated mainly by sequencing by hybridization SBHand in some cases, sequences obtained from one or more public databases.
The invention relates also to the proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides LG GCR-8521A proteins. The nucleic acids and polypeptides are provided in the Sequence Listing.
In the nucleic acids provided in the Sequence Listing, A is adenosine ; C is cytosine ; G is guanine ; T is thymine ; and N is any of the four bases. The nucleic acid sequences of the LG GCR-8521A invention also include, nucleic acid sequences that hybridize to the complement of SEQ ID NO: The identifying sequence can be base pairs in length.
The nucleic acid sequences of the present invention also include the sequence information from the nucleic acid LG GCR-8521A of SEQ ID NO: A collection as used in this application can be a collection of only one polynucleotide. LG GCR-8521A
The collection of sequence information or identifying information of each sequence can LG GCR-8521A provided on a nucleic acid array. In one embodiment, segments of sequence information is provided on a nucleic acid LG GCR-8521A to detect the polynucleotide that contains the segment.